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2010•Zhongguo fuyou baojianRequires access

Investigation on inhibitory effect of mifepristone on cell proliferation of endometrial carcinoma

Yang Li

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Abstract

Objective:To explore the effect of mifepristone on apoptosis, cell cycle and subtypes of progesterone receptor in patients with endometrial carcinoma.Methods:60 samples were extracted before and after treatment of mifepristone, the rate of cell apoptosis and changes of cell cycle were detected by flow cytometry, the expression levels of PR-A mRNA and PR-B mRNA were detected by real-time quantitative PCR.Results:After treated with mifepristone, the apoptosis rate of cancer cells and ratio of G0/G1 increased, the ratio of S phase decreased, the expression of PR-B mRNA and the ratio of PR-B/PR-A decreased significantly.Conclusion:Mifepristone can down-regulate the expression of PR-B, block cancer cells at G1 phase, promote apoptosis and inhibit the growth of endometrial carcinoma cells.

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What this paper is about

Objective:To explore the effect of mifepristone on apoptosis, cell cycle and subtypes of progesterone receptor in patients with endometrial carcinoma.Methods:60 samples were extracted before and after treatment of mifepristone, the rate of cell apoptosis and changes of cell cycle were detected by flow cytometry, the expression levels of PR-A mRNA and PR-B mRNA were detected by real-time quantitative PCR.Results:After treated with mifepristone, the apoptosis rate of cancer cells and ratio of G0/G1 increased, the ratio of S phase decreased, the expression of PR-B mRNA and the ratio of PR-B/PR-A decreased significantly.Conclusion:Mifepristone can down-regulate the expression of PR-B, block cancer cells at G1 phase, promote apoptosis and inhibit the growth of endometrial carcinoma cells.

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Available abstract

Objective:To explore the effect of mifepristone on apoptosis, cell cycle and subtypes of progesterone receptor in patients with endometrial carcinoma.Methods:60 samples were extracted before and after treatment of mifepristone, the rate of cell apoptosis and changes of cell cycle were detected by flow cytometry, the expression levels of PR-A mRNA and PR-B mRNA were detected by real-time quantitative PCR.Results:After treated with mifepristone, the apoptosis rate of cancer cells and ratio of G0/G1 increased, the ratio of S phase decreased, the expression of PR-B mRNA and the ratio of PR-B/PR-A decreased significantly.Conclusion:Mifepristone can down-regulate the expression of PR-B, block cancer cells at G1 phase, promote apoptosis and inhibit the growth of endometrial carcinoma cells.

Key concepts: Mifepristone, Apoptosis, Flow cytometry, Medicine, Cell cycle, Carcinoma, Progesterone receptor, Messenger RNA

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