Comparetive Observation of Theraputic Effect of Valsartan and Felodipin in Treatment of Grade I、II Essential Hypertension

Objective To evaluate the efficacy of Valsartan and Felodipin treating the Chinese patients with mild to moderate essential hypertension.Methods Patients with mild to moderate essential hypertension [sitting diastolic blood pressure (SiDBP) of 90 ～109 mm Hg,systolic blood pressure (SiSBR) of 140 ～179 mm Hg] (n =132) were selected and devided into two groups by double-blind randomized study,Every group has 66 patients.The patients of treatment group were treated with Valsartan 80 mg/d and control group with Felodipin 5 mg/d for comparison of efficacy.All of the patients were treated for 6 weeks.Blood Pressure was examined before the treatment and at the end of 2、4、6、8 weeks.Results At the end of 8 weeks,no statistical difference was found in the antihypertensive effect between the two drugs (P0.05).SiSBP/SiDBP in the treatment group were reduced by (32.8 ±11.0/13.0±6.4) mm Hg by Valsartan and SiSBP/SiDBP in control group were lowered by (29.3 ±8.6/11.8 ±7.9) mm Hg by Felodipin.Conclusion Valsartan and Feloeipin were effective and well tolerated in Chinese patients with grade Ⅰ、Ⅱ essential hypertension with little side effect.Valsartan is a satisfactory drug in the treatment of hypertension.