Early detection of bladder cancer by urine survivin and urinary cytology

Objective To investigate the application value of detection of survivin in urine combined with examination of cells in the diagnosis of bladder cancer. Methods Urine specimens were collected from 4 groups: healthy volunteers (n=8) and patients with nonneoplastic urinary tract disease (n=9), other genitourinary cancer (n=22), new-onset or recurrent bladder cancer(n=47). Survivin levels were analyzed by ELISA detection system and examinations of exfoliated cells were taken at the same time. Results The ratio of survivin detected in urine from the patients with bladder cancer was much higher than other groups(P0.01), as to the same patients examination of exfoliated cells had lower masc ratio(P0.01) but higher specificity(P0.05) than detection of urine survivin, and this difference was correlated with grades of bladder cancer. Conclusions Detection of urine survivin combined with examination of exfoliated cells may make for elevating sensitivity and specificity of bladder cancer diagnosis.