The Clinical Application of Multi-slice Spiral CT Perfusion Imaging in Cirrhosis with Portal Hypertension

Purpose: To evaluate the clinical application of multi-slice spiral CT Perfusion Imaging in cirrhosis with portal hypertension.Materials and Methods: 43 cases liver cirrhosis were involved in this study,which were divided into 4 groups according to portal hypertension complication(hemorrhage of upper digestive tract,hydroperitoneum).The liver perfusion parameters were obtained by color perfusion map method.Control subjects were 30 cases of normal persons.Results: The liver perfusion parameters of control group,pure liver cirrhosis group,hemorrhage group,hydroperitoneum group and mixed group were respectively hepatic arterial perfusion(HAP): 24.80±5.84,18.09±6.65,23.44±11.08,20.94±7.23 and 17.29±3.41 ml·min-1·100ml-1.The portal venous perfusion(PVP) was 104.91±21.70,91.68±20.14,78.43±28.92,67.26±12.95 and 54.08±3.88 ml·min-1·100ml-1.The total liver perfusion(TLP) was 129.90±25.19,109.76±21.22,101.86±25.11,88.20±13.04 and 71.37±2.89 ml·min-1·100ml-1.The hepatic perfusion index(HPI) was 19.13±3.33,16.82±5.92,24.42±14.34,23.96±8.18 and 24.22±4.65.There was significant difference among study groups(P0.05).Regarded 97.1 ml ·min-1·100 ml-1 as threshold,which was average value of TLP of 43 cases of liver cirrhosis in this study,its positive predictive value and negative predictive value for occurrence of portal hypertension complication was 88.0%,83.3% respectively.Conclusions: Multi-slice spiral CT perfusion imaging can evaluate the hemodynamic changes of cirrhosis with portal hypertension.TLP presented high clinical value to predict occurrence of portal hypertension complication.