The study of correlation between expression and prognosis of IL-6,IL-8,IL-10 and TNF in the multiple injury

Objective To investigate the effect of inflammatory cytokines interleukin-6(IL-6),interleukin-8(IL-8),interleukin-10(IL-10) and tumor-necrosis factor(TNF) in multiple injury.Methods Multiple injury(20 cases),single injury(20 cases),controls(20 healthy cases) were detected for IL-6,IL-8,IL-10,TNF in serum at 1,3,5,7 and 9 day respectively by radioimmunoassay.Results IL-6,IL-8 and TNF in serum of multiple injury patient increased significantly,the crest was 3～5 d later after trauma,and decreasing 5 days later,the difference among the groups was significant(P0.01),the peak value in single injury group was low and transient.IL-10 in serum of multiple trauma patient attained the high level at 72 h after the trauma,and decreased gradually at 6～7 d,the difference was significant (P0.01).Conclusion IL-6,IL-8 and TNF are pro-inflammatory cytokines,IL-10 is anti-inflammatory cytokine,they play an important role in the development of diseases,it is the key time of treatment at 1～5 d after trauma.Monitoring IL-6,IL-8,IL-10,TNF in serum in time,and monitoring life sign,biochemical parameters at the same time could sensitively observe the effect of treatment and forecast the trend of diseases in multiple injury patients.