2006•Journal of Apoplexy and Nervous DiseasesRequires access
Expression of NGF and BDNF after cerebral infarction and cerebral infarction combined with diabetes in rats brain
Zhang Chao-don
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Abstract
Objective To study the expression of nerve growth factor(NGF) and brain-derived neurotropic factor (BDNF) after permanent local cerebral ischemia in cerebral infarction or cerebral infarction combined with diabetes in SD rat brain. Methods SD rats were divided into three groups :control group,simple focal cerebral infarction group and cerebral infarction combined with diabetes group. The model of diabetic was made by 2%STZ injection into abdomen by 60mg/kg,MCAO was induced with an intraluminal filament model as described earlier. The protein expression of NGF and BDNF were determined by immunohistochemistry. Results The control group had little expression of NGF and BDNF. Expression of NGF and BDNF were elevated in the perifocal area in both experimental groups after MCAO which were more higher in single cerebral infarction group than in cerebral infarction combined with diabetes. Conclusion The expression of NGF and BDNF are induced after focal cerebral ischemia, which may contribute to neuprotection in the cortex of ischemic brain.