Research Progress of the Relationship between p38 Mitogen-activated Protein Kinase and Cerebral Ischemia

Mitogen-activated protein kinase(MAPK) is an integration point of different signal transduction pathways.Many tyrosine kinases can be activated by stimulating the signaling cascade of MAPK pathway.p38 MAPK,as one of the major MAPK family member,is activated and plays an essential role in early stage of ischemic neuronal injury,involved in inflammatory response,cytokine secretion,cell apoptosis,playing an important regulating role in cerebral ischemia neuronal death.Inhibitor of p38 MAPK is expected to be a new effective clinical treatment for cerebral ischemia.