Tirofiban in Emergency Percutaneous Coronary Curative Effect Analysis of Elderly Acute ST-elevation Myocardial Infarction

Objective To discuss the curative effect of tirofiban on myocardial reperfusion used before percutaneous coronary intervention(PCI) in the old patients with acute ST-elevation myocardial infarction(STEMI).Methods A total of 78 old patients acute STEMI were enrolled in the trial from Jan.2011 to Dec.2013;they were randomly divided into 2 groups:tirofiban group(n=40) and placebo group(n=38).The control group was given aspirin and clopidogrel and other drugs,and the tirofiban group,tirofiban besides routine treatment.The influences of tirofiban on coronary blood flow,30 days mace and 60 days mace(especially angina pectoris and myocardial infarction cardiac infarction) and bleeding were observed.ResultS The occurrence of TIMI grade 1 flow before PCI,and occurrence of TIMI grade 3 and 2 after PCI in the tirofivan group were superior to those in the control group(P0.05).The comparisons in 30 days mace and 60 days mace(especially angina pectoris and myocardial infarction cardiac infarction) after PCI between two groups showed statistical differences(P0.05).The percentage of mild bleeding was 10.0%in the tirofiban group and 10.53%in the control group and the difference was not statistically significant(P0.05).Conclusion Tirofiban can improve TIMI flow before and after PCI and is helpful to reperfusion of ischemia myocardial,but don't increases the risk of mild bleeding.