The effects of chronic swimming training on ET-1 protein in plasma and thoracic aorta in rats

To investigate the effect of different chronic swimming training on endothelin-1 in plasma and thoracic aorta in rats. Methods:2 months old SD male rats were divided into control group and 14-week swimming training groups. Swimming training rats were divided into (one-hour) swimming training per day(6 days/week),two-hour swimming training per day(6 days/week),and one-hour swimming training per day(3 days/week). ET-1 protein in thoracic aorta and plasma,the level of SOD,MDA and T-AOC in serum were determined. Body weights were measured periodically. Results:(1)The body weights significantly lowered in swimming training rats compared with control group. (2)Compared with control group,the concentration of the (plasma) ET-1 increased lightly but there were no significant differences in swimming training groups,except that the difference in E2Y was significant,and the concentration of ET-1 in (thoracic) aorta did not change significantly in swimming training rats. (3)There is no cause-effect relationship between the concentration of ET-1 in thoracic aorta and plasma and the level of SOD,MDA and T-AOC in serum. Conclusions:Swimming training can reduce the body weight of rats,which maybe contribute to lower the dangers of cardiovascular diseases. After swimming training,the concentration of the plasma ET-1 increased moderately,which may contribute to strenthen myocardial constriction. It has not been found that there was cause-effect relationship between ET-1 level and oxidative stress.