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HPLC fingerprint of Radix Puerariae from Ankang,Shaanxi Province

Zhichao Zhang

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Abstract

Objective To establish HPLC fingerprint of Radix Puerariae from Ankang,Shaanxi Province.Methods Inertisil C18 column(250 mm×4.6 mm,5 μm) was used,with methanol-acetonitrile-0.25% acetic acid solution as mobile phase in a gradient elution.Flow rate was 1.0 mL/min.The wavelength was 250 nm.Results For the relative retention time and relative area of common peaks,the RSD of ten batches of crude drug samples were below 10%.The similarities accorded with the regulation.Conclusion The analytical method can be used for the quality control of Radix Puerariae and of its sterilized powder for injection.

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What this paper is about

Objective To establish HPLC fingerprint of Radix Puerariae from Ankang,Shaanxi Province.Methods Inertisil C18 column(250 mm×4.6 mm,5 μm) was used,with methanol-acetonitrile-0.25% acetic acid solution as mobile phase in a gradient elution.Flow rate was 1.0 mL/min.The wavelength was 250 nm.Results For the relative retention time and relative area of common peaks,the RSD of ten batches of crude drug samples were below 10%.The similarities accorded with the regulation.Conclusion The analytical method can be used for the quality control of Radix Puerariae and of its sterilized powder for injection.

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Available abstract

Objective To establish HPLC fingerprint of Radix Puerariae from Ankang,Shaanxi Province.Methods Inertisil C18 column(250 mm×4.6 mm,5 μm) was used,with methanol-acetonitrile-0.25% acetic acid solution as mobile phase in a gradient elution.Flow rate was 1.0 mL/min.The wavelength was 250 nm.Results For the relative retention time and relative area of common peaks,the RSD of ten batches of crude drug samples were below 10%.The similarities accorded with the regulation.Conclusion The analytical method can be used for the quality control of Radix Puerariae and of its sterilized powder for injection.

Key concepts: Radix (gastropod), Chromatography, Gradient elution, High-performance liquid chromatography, Acetic acid, Fingerprint (computing), Chemistry, Crude drug

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