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Activation of MAPKP38 signal transduction pathway in rat hippocampal formation after experimental seizure

Jie Xia

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Abstract

Objective To investigate the spatiotemporal distribution pattern of active p38 in rat hippocampal formation following pilocarpine-induced status epilepsy(SE) and to discuss the significance.Methods The lithium-pilocarpine-induced model of SE was established to evaluate the phosphorylation forms of p38(P-p38) by immunohistochemistry and histopathology changes were observed at different times after pilocarpine injection.Results In pilocarpine-treated rats,the hippocampal neurons showed a strong immunoreativity of P-p38 in the body at 30 min after pilocarpine injection,while decreased markedly at 6h.There were more immunoreactive positive cells in the dentate gyrus than those in regions of CA1 and CA3.Many injured neurons were found in hippocampus of SE rats.Conclusion p38MAPK signal transduction pathyway can be activated in SE induced by pilocapine,and may play a critical role in neurons vulnerability in regions of CA1 and CA3 after epilepsy.

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Objective To investigate the spatiotemporal distribution pattern of active p38 in rat hippocampal formation following pilocarpine-induced status epilepsy(SE) and to discuss the significance.Methods The lithium-pilocarpine-induced model of SE was established to evaluate the phosphorylation forms of p38(P-p38) by immunohistochemistry and histopathology changes were observed at different times after pilocarpine injection.Results In pilocarpine-treated rats,the hippocampal neurons showed a strong immunoreativity of P-p38 in the body at 30 min after pilocarpine injection,while decreased markedly at 6h.There were more immunoreactive positive cells in the dentate gyrus than those in regions of CA1 and CA3.Many injured neurons were found in hippocampus of SE rats.Conclusion p38MAPK signal transduction pathyway can be activated in SE induced by pilocapine,and may play a critical role in neurons vulnerability in regions of CA1 and CA3 after epilepsy.

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Available abstract

Objective To investigate the spatiotemporal distribution pattern of active p38 in rat hippocampal formation following pilocarpine-induced status epilepsy(SE) and to discuss the significance.Methods The lithium-pilocarpine-induced model of SE was established to evaluate the phosphorylation forms of p38(P-p38) by immunohistochemistry and histopathology changes were observed at different times after pilocarpine injection.Results In pilocarpine-treated rats,the hippocampal neurons showed a strong immunoreativity of P-p38 in the body at 30 min after pilocarpine injection,while decreased markedly at 6h.There were more immunoreactive positive cells in the dentate gyrus than those in regions of CA1 and CA3.Many injured neurons were found in hippocampus of SE rats.Conclusion p38MAPK signal transduction pathyway can be activated in SE induced by pilocapine,and may play a critical role in neurons vulnerability in regions of CA1 and CA3 after epilepsy.

Key concepts: Pilocarpine, Hippocampal formation, Dentate gyrus, Hippocampus, Epilepsy, Neuroscience, Internal medicine, Endocrinology

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