Expressions and correlation of Livin protein and Caspase-3protein in invasive ductal breast cancer tissues

OBJECTIVE:To investigate the expression and correlation of Livin protein and Caspase-3protein in invasive ductal breast cancer tissues.METHODS:The expression of Livin protein in 70cases of invisive ductal breast cancer,20cases of breast hyperplasia,10cases of adjacent normal breast tissue were tested with SP immunohistochemistry(IHC),and their correlation with some clinical pathological parameters was detected.RESULTS:Livin expression in breast cancer tissues were 64.3%,and significantly higher than 25.0% of benign lesions and 10.0% of adjacent normal tissues(P0.05);The positive expression of Caspase-3in 70breast carcimoma examples was 45.7%,while 75.0%in benign breast lesions,and 80.0%in adjacent tissues and there was significant difference among them(P0.05).Livin proteins in breast cancer tissues were negatively correlated with Caspase-3proteins(P0.05).There was a increased trend of the Livin protein expression with the increase in the clinical stage(P0.05),Livin protein expression in breast cancer were relevant to the clinical stage(P0.05),but irrelevant to the age,tumor size,the histologic grade and lymph node metastasis(P 0.05).There was a reduced trend of the Caspase-3expression with the increase in the clinical stage(P0.05),but irrelevant to the age,tumor size,histologic grade and lymph node metastasis(P0.05).Livin protein were negatively related to ER and PR in breast cancer tissues(P0.05),but uncorrelated with c-erbB-2proteins(P 0.05),Caspase-3proteins were related to ER and PR in breast cancer tissues(P0.05),but uncorrelated with c-erbB-2proteins(P0.05).CONCLUSIONS:Livin overexpressed in breast cancer tissues,suggesting that they may play an important role in invisive ductal breast cancer inogenesis and development,and they may become makers in the diagnosis of breast cancer and a new point of target therapy.Caspase-3is negatively related to Livin,suggesting that Caspase-3protein plays an important role in the anti-apoptotic pathway of Livin.