A retrospective analysis of prognosis on patients with severe hepatitis using the model for end-stage liver disease

Objective To study the practical use of the model for end-stage liver disease(MELD) in clinics and the role of artificial liver support system(ALSS) in end-stage liver disease by retrospective analysis of prognosis on patients with severe hepatitis.Methods 156 patients with severe hepatitis were divided into a plasma exchange(PE) group and a non-plasma exchange(non-PE) group,changes of MELD score before and after PE treatment 2 weeks and the death rate within 3 months were observed.Results After treatment 2 weeks serum bilirubin,INR,Cr,MELD score and MELD in 20~29,30~39 group were significant lower in PE group than non-PE group(P0.01).The mortality rate and MELD score in PE group were significant lower than those in non-PE group.The higher MELD score,the higher mortality rate of patients.The mortality rates of patients were 100% in PE group and non-PE group when MELD score was above 40.Conclusion ALSS has good therapeutic efficacy in the treatment of severe hepatitis.The mortality rates of patients increase with their MELD scores.MELD can accurately predict the short-term prognosis of patients with severe hepatitis.