Characteristics of Coronary Atherosclerosis and Peripheral Blood Th cell changes in Acute Coronary Syndromes with Impaired Glucose Regulation.

Objective To evaluate the characteristics of coronary atherosclerosis and peripheral blood Th cell changes in acute coronary syndromes(ACS)with Impaired glucose regulation.Methods 56 ACS patients were divided into two groups by the results of OGTT test:Group A:ACS with impaired glucose regulation(IGR);Group B:ACS with normal glucose metabolism.Coronary angiography was performed and Coronary Atherosclerosis Gensini score was calculated in all patients.Peripheral blood monouclear cells were cultured for 48 hours,cytokines IFN-γ and IL-4 were detected in supernatant.Results Compared with group B,Gensini score(13.64±3.11 vs 9.23±2.72,P0.05) and IFNγ secretion increased in group A,indicated that the type 1 Th was further activated and the Th1/Th2 ratio in group A was higher than that in group B.Conclusion Compared with ACS with normal glucose metabolism,coronary atherosclerosis was extensive and the extent of inflammation was greater in ACS combined with IGR,showed the reinforced clinical intervention was essential.