Antihypertension and protection of SNP on brain at peri-operative duration for hypertension patients with bleeding

Objective To investigate the effects of the (Sodium Nitroprusside) SNP in antihypertension and pretecting brain at perioperative duration for patient with bleeding in brain caused by hypertension. Method The 56 patients divided into two groups random the SNP group (36 patients) and the NTG group (20 patients). The HR,MAP,SjVO2 were measured at perioperative duration, and mortality after operation was calculated. Result After used drug, the patients in the SNP group had a great improvemen in HR, MAP, SjVO2, but the changes in the NTG group had no evidence. The mortality in the SNP group had greatly be reduced than in the NTG group. Conclusion SNP has the effect of depressing resistance of exterior vas, alleviating pre-load of heart, decreasing exuberate pressure in left ventricle, improving heart function without lowering of cardiac output, thus improving ischemia and anoxia in important organs of body, and the range of depressing pressure is windless, recovery of pressure is rapidly. Application of SNP in the operation seriate can make protein S100 release reduced, and then to protect the glia cell postponly. SNP has a good effect in antihypertension and pretecting brain tissue at perioperative duration for patient with bleeding in brain caused by hypertension.