Effect of chicken collagen type II on collagen-induced arthritis in mice

AIM To investigate the effect of chicken collagen type Ⅱ (CⅡ) on collagen-induced arthritis (CIA) mice. METHODS The model of mice CIA was prepared and the change of the mean of arthritis scores was observed. Meanwhile, ConA and LPS-induced splenocytes proliferation and the production of interleukin (IL)-1 and IL-2 were measured. RESULT CⅡ [5, 10, 20 μg·kg -1 ig×7 d] significantly decreased the mean of arthritis scores, inhibited the increased ConA-induced splenocytes proliferation as well as the elevated production of IL-1 and IL-2. Meanwhile, the pathological examination showed that articulus cartilage degeneration with synovial hyperplasia and inflammatory cells infiltration in CIA mice was suppressed by ig CⅡ. CONCLUSION CⅡ has therapeutical effect on mice CIA which may be related to its immunoregulative function.