2012•Modern Practical MedicineRequires access
Effect of leflunomide on the monocyte chemoattractant protein-1 expression in type 2 diabetic rats
Jin Li
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Abstract
Objective To investigate the effect of leflunomide(LEF) on monocyte chemoattractant protein-l(MCP-1) in type 2 diabetic rats.Methods Thirty Wistar rats of eight weeks were established as diabetic models induced by STZ.Witar rats were divided into three groups:normal control rats,diabetic rats treated with LEF,diabetic rats treated with saline,with 10 rats in each group.Seven weeks later,laboratory data,kidney pathology,expressions of MCP-l and monocyte/macrophage cell surface antigen(ED-1) by inmmunohistochemistry were compared.Results Compared with the group of diabetic rats treated with saline,urinary albumin excretion of LEF treated rats were substantially decreased.The expressions of MCP-l and ED-l in LEF group were much lower than those in the diabetic rats treated with saline.LEF also improved the histological changes of diabetic rats.Conclusion LEF has some renal protective effects on type 2 diabetic rats by inhibition expression of MCP-l.