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1983•The Journal of Toxicological SciencesOpen access

EFFECTS ON OFFSPRINGS INDUCED BY ORAL ADMINISTRATION OF RANITIDINE TO THE FEMALE RAT IN PERIAND POSTNATAL PERIODS

Noriko Higashida, Masako SAKANOUE, Satoru KAMADA, Masaya Takeuchi, Kotaro SHIMPO, Tsuneyoshi Tanabe

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Abstract

A perinatal and postnatal study was carried out in the Crj:CD (SD) rats orally administered ranitidine hydrochloride, a histamine H2-receptor antagonist, at dose levels of 50, 200, and 800 mg/kg/day as base for a period of time from day 17 of gestation to day 21 after delivery. All pregnant rats were allowed to litter naturally, and the postnatal development of the offsprings was observed. In the 800 mg/kg group, the delivery rate was significantly decreased and offspring mortality during the lactation period showed a tendency to increase as compared with control, but the difference was not significant. No significant differences between the control group and the treated groups were found in postnatal growth and differentiation, behavior and reproductive ability of male and female offsprings.

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A perinatal and postnatal study was carried out in the Crj:CD (SD) rats orally administered ranitidine hydrochloride, a histamine H2-receptor antagonist, at dose levels of 50, 200, and 800 mg/kg/day as base for a period of time from day 17 of gestation to day 21 after delivery. All pregnant rats were allowed to litter naturally, and the postnatal development of the offsprings was observed. In the 800 mg/kg group, the delivery rate was significantly decreased and offspring mortality during the lactation period showed a tendency to increase as compared with control, but the difference was not significant. No significant differences between the control group and the treated groups were found in postnatal growth and differentiation, behavior and reproductive ability of male and female offsprings.

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Available abstract

A perinatal and postnatal study was carried out in the Crj:CD (SD) rats orally administered ranitidine hydrochloride, a histamine H2-receptor antagonist, at dose levels of 50, 200, and 800 mg/kg/day as base for a period of time from day 17 of gestation to day 21 after delivery. All pregnant rats were allowed to litter naturally, and the postnatal development of the offsprings was observed. In the 800 mg/kg group, the delivery rate was significantly decreased and offspring mortality during the lactation period showed a tendency to increase as compared with control, but the difference was not significant. No significant differences between the control group and the treated groups were found in postnatal growth and differentiation, behavior and reproductive ability of male and female offsprings.

Key concepts: Ranitidine, Administration (probate law), Medicine, Pharmacology, Oral administration, Internal medicine, Physiology, Endocrinology

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EFFECTS ON OFFSPRINGS INDUCED BY ORAL ADMINISTRATION OF RANITIDINE TO THE FEMALE RAT IN PERIAND POSTNATAL PERIODS — Research Paper | ScholarLens