The study of hepatic perfusion after liver transplantation on MSCT

Objective:To compare hepatic perfusion values after orthotopic liver transplantation with those without hepatic diseases using dynamic single slice CT scanning.Methods:30 patients during perioperation with no complications and 20 normal volunteers were performed dynamic single slice CT scanning.ROIs were in hepatic hilus including liver,portal vein,aorta and spleen.CT scan was obtained over 50 seconds(one baseline scan followed by 35 scans every 1 second) beginning with the injection of 40ml of contrast agent (flow rate 3ml/sec).On each scan,the attenuation of these organs was measured in regions of interest to provide for time attenuation curves and the value of perfusion.12 patients after perioperation (2～3months) with no complications were also performed single slice dynamic CT scanning.Results:Of the control subjects and perioperational patients,hepatic artery perfusion was 0.16 and 0.27ml/min,respectively( P 0.05);portal vein perfusion was 1.13 and 1.31ml/min,respectively( P 0.05);total liver perfusion was 1.28 and 1.68ml/min ( P 0.05);and mean hepatic artery perfusion index 0.19 and 0.13respectively( P 0.05).Hepatic artery perfusion and portal vein perfusion after perioperation was 0.16ml/min( P 0.05) and 1.21ml/min,respectively( P 0.05).Total liver perfusion index and artery perfusion index was 1.20ml/min( P 0.05)and 0.13ml/min( P 0.05),respectively.Conclusion:Hepatic artery perfusion,total hepatic perfusion and hepatic artery perfusion index increase significantly during perioperation,but portal vein perfusion has no obvious changes.After perioperation,hepatic artery perfusion remains unchanged,but portal vein perfusion increases.It is helpful for evaluating posttransplantation hepatic perfusion using dynamic single slice MSCT.