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2012•Journal of psychiatryRequires access

A comparative study of escitalopram vs.venlafaxine in the treatment of depression

Zhang Dannin

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Abstract

Objective To explore the efficacy of escitalopram vs.venlafaxine in improving symptoms of depression.Methods 123 patients with depression were randomly divided into study group(62 cases) treated with escitalopram and control group(61 cases) treated with venlafaxine for 4 weeks.All patients were assessed with Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA) and Treatment Emergent Symptom Scale(TESS) at baseline and the 1st,2nd,4th weekend of treatment.Results Scores of HAMD and HAMA in both groups at the 1st weekend decreased significantly compared with the baseline(P0.05).Score of HAMD in study group were significantly lower than that in control group at the 1st weekend(P0.05).Score of HAMA in control group were significantly lower than that in study group at the end of the treatment HH(P0.05).The total efficacy in both groups were equivalent(P0.05).There was no severe side effect in the two groups(P0.05).Conclusion Both escitalopram and venlafaxine is effective and safe in the treatment of depression.Escitalopram takes effect more faster in improving depressive symptoms,venlafaxine is more effective in improving anxiety symptoms.

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Objective To explore the efficacy of escitalopram vs.venlafaxine in improving symptoms of depression.Methods 123 patients with depression were randomly divided into study group(62 cases) treated with escitalopram and control group(61 cases) treated with venlafaxine for 4 weeks.All patients were assessed with Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA) and Treatment Emergent Symptom Scale(TESS) at baseline and the 1st,2nd,4th weekend of treatment.Results Scores of HAMD and HAMA in both groups at the 1st weekend decreased significantly compared with the baseline(P0.05).Score of HAMD in study group were significantly lower than that in control group at the 1st weekend(P0.05).Score of HAMA in control group were significantly lower than that in study group at the end of the treatment HH(P0.05).The total efficacy in both groups were equivalent(P0.05).There was no severe side effect in the two groups(P0.05).Conclusion Both escitalopram and venlafaxine is effective and safe in the treatment of depression.Escitalopram takes effect more faster in improving depressive symptoms,venlafaxine is more effective in improving anxiety symptoms.

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Available abstract

Objective To explore the efficacy of escitalopram vs.venlafaxine in improving symptoms of depression.Methods 123 patients with depression were randomly divided into study group(62 cases) treated with escitalopram and control group(61 cases) treated with venlafaxine for 4 weeks.All patients were assessed with Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA) and Treatment Emergent Symptom Scale(TESS) at baseline and the 1st,2nd,4th weekend of treatment.Results Scores of HAMD and HAMA in both groups at the 1st weekend decreased significantly compared with the baseline(P0.05).Score of HAMD in study group were significantly lower than that in control group at the 1st weekend(P0.05).Score of HAMA in control group were significantly lower than that in study group at the end of the treatment HH(P0.05).The total efficacy in both groups were equivalent(P0.05).There was no severe side effect in the two groups(P0.05).Conclusion Both escitalopram and venlafaxine is effective and safe in the treatment of depression.Escitalopram takes effect more faster in improving depressive symptoms,venlafaxine is more effective in improving anxiety symptoms.

Key concepts: Escitalopram, Hamd, Venlafaxine, Depression (economics), Hamilton depression scale, Anxiety, Internal medicine, Psychology

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