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2011•Zhongguo fuyou baojianRequires access

Expression and significance of vascular endothelial growth factor in patients with intrahepatic cholestasis of pregnancy

Jian Xu

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Abstract

Objective:To explore the relationship between vascular endothelial growth factor(VEGF) and pathogenesis of intrahepatic cholestasis of pregnancy(ICP).Methods:The expression levels of VEGF in venous serum,amniotic fluid and umbilical venous serum of 30 pregnant women with ICP(observation group) and 30 normal pregnant women(control group) were detected by ELISA.Results:The expression levels of VEGF in venous serum,amniotic fluid and umbilical venous serum in observation group were significantly lower than those in control group(P0.01).Conclusion:The significant decrease of expression level of VEGF may play an important role in the pathogenic mechanism of ICP.

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Objective:To explore the relationship between vascular endothelial growth factor(VEGF) and pathogenesis of intrahepatic cholestasis of pregnancy(ICP).Methods:The expression levels of VEGF in venous serum,amniotic fluid and umbilical venous serum of 30 pregnant women with ICP(observation group) and 30 normal pregnant women(control group) were detected by ELISA.Results:The expression levels of VEGF in venous serum,amniotic fluid and umbilical venous serum in observation group were significantly lower than those in control group(P0.01).Conclusion:The significant decrease of expression level of VEGF may play an important role in the pathogenic mechanism of ICP.

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Available abstract

Objective:To explore the relationship between vascular endothelial growth factor(VEGF) and pathogenesis of intrahepatic cholestasis of pregnancy(ICP).Methods:The expression levels of VEGF in venous serum,amniotic fluid and umbilical venous serum of 30 pregnant women with ICP(observation group) and 30 normal pregnant women(control group) were detected by ELISA.Results:The expression levels of VEGF in venous serum,amniotic fluid and umbilical venous serum in observation group were significantly lower than those in control group(P0.01).Conclusion:The significant decrease of expression level of VEGF may play an important role in the pathogenic mechanism of ICP.

Key concepts: Medicine, Cholestasis of pregnancy, Vascular endothelial growth factor, Amniotic fluid, Pathogenesis, Placenta, Venous blood, Internal medicine

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Expression and significance of vascular endothelial growth factor in patients with intrahepatic cholestasis of pregnancy — Research Paper | ScholarLens