Surveillance of bacterial resistance in Tianjin of the fourth quarter of 2011

OBJECTIVE To establish a level bacterial resistance surveillance network in Tianjin and get information about bacterial resistance for assisting the clinical use of antibacterials and providing objective material in administration of antibacterials.METHODS Twenty-two hospitals in Tianjin were involved in this program.Bacterial susceptibility testing was carried out with automatic microbiological system method.All the bacterial susceptibility results of the fourth quarter of 2011 were processed with WHONET5.4 software and analyzed according to CLSI 2008 breakpoints.RESULTS A total of 15 880 bacterial isolates and their antibacterial susceptibility data were collected,which included 4376(27.6%) strains of gram-positive bacteria and 11 504(72.4%) strains of gram-negative bacteria.Staphylococcus(2724 strains),Enterococcus(997 strains) and Streptococcus(575 strains) were the most common gram-positive isolates.Klebsiella pneumoniae(2507 strains),Escherichia coli(2490 strains) and Pseudomonas aeruginosa(1637 strains) were the top three gram-negative isolates,accounting for 21.8%,21.6%,and 14.2%,respectively.The detection rates of methicillin-resistant S.aureus(MRSA) and methicillin-resistant coagulase-negative Staphylococcus(MRCNS) were 38.8% and 71.1%.Regarding non-meningitis S.pneumoniae strains,the rate of penicillin non-susceptible in adults(18.7%) was lower than that in the children′s(43.8%).Glycopeptides-resistant Enterococcus were detected.The drug resistance rates of E.faecalis and E.faecium to vancomycin were 0.4% and 3.6%,respectively,the drug resistance rates to teicoplanin were 1.1% and 4.6%,respectively.Quinolone-resistant E.coli was about 53%.The prevalence of ESBLs-producing strains was 34.4% in E.coli and 19.7% in K.pneumoniae.The Enterobacteriaceae strainswere still highly susceptible to carbapenems.Overall less than 1% of these strains were resistant to carbapenems.About 20.1% and 18.6% ofP.aeruginosa strains were resistant to imipenem and meropenem.18.9% and 19.9%A.baumannii strains were resistant to imipenem and meropenem. CONCLUSION The bacterial resistance surveillance network in Tianjin is established so as to understand the current status of bacterial resistance of clinical isolates in Tianjin.The bacterial resistance keeps an upward tendency,which should be attached great importance.