Clinical significance of combined detection serum tumor markers in patients with lung cancer

Objective To study the clinical significance of single or combination detection serum tumor markers CEA,CA153,CA199 and SF in patients with lung cancer.Methods The CEA,CA153,CA199 and SF were assayed in 70 patients with lung cancer,68 patients with benign lung disease and 62 cases of normal control.The sensitivities and specificities of different tumor markers and the combined for the diagnosis of lung cancer were evaluated and compared.Results The levels of serum CEA,CA153,CA199 and SF in lung cancer patients were significantly higher than that in benign lung disease patients and normal controls(P0.05).The level of CEA and CA153 in adenocarcinoma were significantly higher than that of other pathology types(P0.05),and the level of CA 199 in small cell lung cancer was significantly higher than that of other pathology types(P0.05).The sensitivity of combination detection(87.7%) were significantly higher than that of single item(62.3%,56.1%,57.3%and 62.4%,respectively). Conclusion The combined detection of CEA,CA153,CA199 and SF could increase the diagnostic sensitivity of lung cancer,it was proved to be as useful reference for differentiation of the lung cancer and benign lung diseases, even for different pathology types.