Cerebral hemodynamics before and after treatment of acute cerebral infarction: CT perfusion imaging

Objective To observe and measure the changes of cerebral hemodynamics before and after treatment of acute cerebral infarction. Methods Thirty one patients with acute infarction diagnosed clinically from 6 to 22 h after the onset of symptoms, underwent routine CT and multislice CT perfusion imaging (MSCTPI) exmined after onset 1 day, 7-21 day, respectively. In the perfusion images, the cerebral blood flow (CBF), cerebral blood volume (CBV), and time to peak (TP) of patients were measured respectively within the specific regions of interest (ROI) of the brain, and quantitative analysis was performed. Results CBF, CBV on ischemic lesion of patients increased after treatment compared with that before treatment ( t =4.57, P 0.01; t =3.81, P 0.01). TP of the patients after treatment was shorten compared with that before treatment ( t =3.62, P 0.01). Conclusion Significant changes of cerebral hemodynamics exist before and after treatment of acute cerebral infarction, indicting that early intervention is effective in the treatment of acute cerebral infarction.