A Single-blind Study of the Effects of Domestic-Produced Carvedilol and Labetalol in the Treatment of Essential Hypertension

Aim:To compare the efficacy and side effect of domestic carvedilol and labetalol in the treatment of essential hypertension. Methods:Fifty mild to moderate hypertensive patients were randomly allocated to treatments with either carvedilol group(10～20 mg bid, \%n\%= 25) or labetalol group(50～100 mg bid, \%n\%= 25) respetively for 4 weeks. Results:After 4 weeks of administration, systolic and diastolic blood pressure decrease significantly by 11.2±6.7 mmHg and 6.9±16.2 mmHg in carvedilol group while only diastolic blood pressure decrease significantly by 11.1±6.2 mmHg in labetalol group. There were no significantly changes in heart rate in two groups durinng trial. The total effective rate of the two groups were 88% and 84%, and side effects were mild during the trial. Conclusion:Domestic produced carvedilol is an efective,safe,and well tolerated antihypertensive drugs in patients with mild to moderate essential hypertension.