SIONIFICANCE OF nm23 AND p21 EXPRESSION IN GASTRIC CARCINOMAS

By using immunohistochemical methods,the relation of the expression of nm23 and p21 tothe biological behavior and metastasis to the lymph nodes in the primary gastric carcinoma(in 88 cases).The results showed that a significant correlation between the lower-expresion of nm23 and the depth ofcancer inrasion was found.nm23 lower-expressive tumours were associated with a higher incidence ofmetastasis to lymph nodes (92.7%)than were nm23-normal expressive(48.5%,P0.05).Abnormalitiesof p21 expression were found in 65.9% of the 88 primary gastric carcinoma. A significant associations wasfound between p21 over-expression and the morphologic pattern of the tumor and the proliferative activi-ties.The metastatic rate in tumours stained positively for p21(87.9%)were higher than in those with nega-tive p21 staining(53.3%,P0.05).The contributions of nm23 lower- expression and p21 over-expressionto the lymph nodal metatasis were the independent joint action.It is suggested that nm23 lower-expressionand p21 over-expression played significant role in the metastasis to lymph nodes in the primary gastric car-cinoma.nm23 lower expression related with the cancer invasion p21 over-expression with the morphologicpatitern and proliferative activity of gastric carcinomas.