Relation of p53,bc1-2 and nm23 Protein Expression to the Biological Characteristics of Gastric Cancer

Objective To study the relationship between the expression of p53,bcl-2 and nm23 and clinicopathology in the patients with gastric cancer and to probe the correlation among the expression of three kinds of oncogene. Methods Eighty cases of different differentiated gastric cancer, 37 cases of peri-tumor atypical mucosa hyperplasia and 20 cases of normal gastric mucosa were stained by immunohistochemistry (SP method).The expression of p53,bcl-2 and nm23 was analyzed with their relation to histologic type,differentiation,lymph node metastasis and prognosis of gastric carcinoma. Results The positive rates of bcl-2 protein expression in mild,middle and severe peri-tumor atypical hyperplasia were 7.1 % , 18.1 % and 25.0 % . There was no obvious difference among 3 groups ( P 0.05). The bcl-2 positive rates of well-differentiated and poor-differentiated gastric cancer were 78.2 % and 48.5 % respectively, the difference was obvious ( P 0.05). The positive expression rate of p53 protein in well-differentiated gastric cancer was 72.5 % , obviously lower than that of poor-differentiated gastric cancer (86.2 % , P 0.05). The positive rate of nm23 in well-differentiated gastric cancer was 84.3 % , obviously higher than that of poor-differentiated (17.2% ),and the expression rate of non-lymph node metastasis group was higher than that of lymph node metastasis group ( P 0.05). The expression rate of nm23 protein was closely correlated to tumor differentiation and lymph node metastasis ( P 0.05). There was a negative correlation between p53 and bcl-2 expression. Conclusion bcl-2 and p53 can be important indices for tumor differentiation and prognosis. nm23 protein plays an important inhibiting role in the process of gastric cancer metastasis and may be a molecular biological basis for the evaluation of patients prognosis in gastric cancer.