Relationship of the extent and severity of coronary artery disease with impaired glucose tolerance

Objective:To evaluate the correlation of impaired glucose tolerance with the extent and severity of coronary artery disease(CAD) in patients who underwent coronary angiography. Method:A total of 524 consecutive patients who underwent coronary angiography were selected in the study.The extent and severity of angiographic CAD were evaluated by: ①whether or not with CAD by diagnosed by angiography;②the number of diseased vessels;③The CAD Gensini cumulative index.According to 2 h plasma glucose(2 h PG) after oral glucose tolerance test(OGTT),all patients were stratified into three group: group 1: 2 h PG 7.8 mmol/L;group 2: 2 h PG 7.8-11.0 mmol/L;group 3: 2 h PG≥11.1 mmol/L.The CHD risk factors and the lesion degree of coronary arteries were compared among three groups.The relationship of 2 h PG and CAD were analyzed by univariate and multivariate analyses. Result:①The incidence of CHD,the CAD Gensini cumulative index,the incidence of multi-vessel lesions were elevated with the increase of 2 h PG level(P0.05).②After adjusting other influencing factors,there were significantly positive correlation between the number of diseased vessels,the CAD Gensini cumulative index and 2 h PG(P0.05).③Mutivariate stepwise regression analysis showed there were independent correlation of 2 h PG with the diseased vessles(β=0.383,P0.05) and CAD Gensini cumulative index(β=0.304,P0.05).④The Logistic regression analysis showed 2 h PG was the independent risky factor of CH.(OR=2.685,95%CI: 1.257-2.869,P0.01). Conclusion:The extent and severity of angiographic coronary artery disease have significant correlations with the impaired glucose tolerance,and the extent and severity can increase with the increasing 2 h PG.