Relevance of Blood Glucose Levels and Coronary Artery lesion in the Prediabetic Patients With Coronary Heart Disease

Objective To evaluate the correlation of blood glucose levels with the extent and severity of angiographic coronary artery disease(CAD) in patients in prediabetic period.Methods A total of 386 consecutive patients with angiographi-cally diagnosed CAD were selected in the study.The extent and severity of angiographic CAD were diagnosed by:whether or not diffuse lesions;the number of diseased vessels;the CAD Gensini cumulative index.According to fasting plasma glucose(FPG) and 2 h plasma glucose(2 h PG) after oral glucose tolerance test(OGTT),all patients were stratified into four groups:group 1:FPG5.6mmol/L and 2 h PG7.8 mmol/L;group 2:5.6≤FPG7.0 mmol/L and 2 hPG7.8 mmol/L;group 3:FPG5.6mmol/L and 7.8≤2 h PG11.1 mmol/L;group 4:5.6≤FPG7.0 mmol/L and 7.8≤2 h PG11.1 mmol/L.The CHD risk factors and the lesion degree of coronary arteries were compared among four groups.The relation of FPG,2 h PG and CAD were analyzed by univariate and multivariate analyses.Results Compared with group 1,the incidence of diffuse lesions,the CAD Gensini cumulative index,the incidence of mult-vessel lesions were significantly higher in the other three groups(all P0.05),especially group 4.There was no diffence of the incidence of diffuse lesions,the CAD Gensini cumulative index,the incidence of mult-vessel lesions between group 2 and group 3.After adjusting other influencing factors,there were significantly positive correlation between the number of diseased vessels,the CAD Gensini cumulative index and FPG,2 h PG(all P0.05).Conclusion The extent and severity of angiographic coronary artery disease have significant correlations with the impaired glucose tolerance and impaired fasting glucose.