The expression and significance of tumor-associated antigen RCAS1 in non-small cell lung carcinoma

Objective To explore the relationship between the expression of tumor-associated antigen RCAS1(receptor-binding cancer antigen expressed on SiSo cells) and the clinical pathological factors in non-small cell lung carcinoma. Methods Immunohistochemical SABC method was used to detect the expression of RCAS1 in 61 non-small cell lung carcinoma tissues, 10 benign lung tissues and 10 normal lung tissues. The relationship between the expression and clinical pathologic charactors was analyzed. Results The positive rate of RCAS1 in non-small lung carcinoma was significantly higher than that in normal lung tissues (P 0.05). But there was no significant difference between the expression or rate of RCAS1 in non-small cell lung carcinoma and benign lung tissues (P 0.05). RCAS1 expression in non-small cell lung carcinoma was correlated with tumor differentiation and clinical staging (P 0.05). Conclusions RCAS1 may participate in the onset and progression of non-small cell lung carcinoma. RCAS1 may be a new biomarker in the diagnosis, treatment and prognostic evaluation of non-small cell lung carcinoma.