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2010•Huaxi yaoxue zazhiRequires access

Protective effects of baicalin on hepatic fibrosis in mice

Yang Yun-xia

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Abstract

OBJECTIVE To investigate the protective effect of baicalin against carbon tetrachloride( CCl4)-induced hepatic fibrosis in mice.METHODS The experimental model mice of hepatic fibrosis was induced by CCl4.The serum ALT/GPT,AST/GOT,AKP, hepatic hydroxyproline ( HYP) and liver,spleen and thymus index were determined.RESULTS Baicalin significantly reduced serum ALT/GPT,AST/GOT,AKP,HYP and liver index.CONCLUSION Baicalin has a protective effect on hepatic fibrosis induced by CCl4 in mice.

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What this paper is about

OBJECTIVE To investigate the protective effect of baicalin against carbon tetrachloride( CCl4)-induced hepatic fibrosis in mice.METHODS The experimental model mice of hepatic fibrosis was induced by CCl4.The serum ALT/GPT,AST/GOT,AKP, hepatic hydroxyproline ( HYP) and liver,spleen and thymus index were determined.RESULTS Baicalin significantly reduced serum ALT/GPT,AST/GOT,AKP,HYP and liver index.CONCLUSION Baicalin has a protective effect on hepatic fibrosis induced by CCl4 in mice.

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Available abstract

OBJECTIVE To investigate the protective effect of baicalin against carbon tetrachloride( CCl4)-induced hepatic fibrosis in mice.METHODS The experimental model mice of hepatic fibrosis was induced by CCl4.The serum ALT/GPT,AST/GOT,AKP, hepatic hydroxyproline ( HYP) and liver,spleen and thymus index were determined.RESULTS Baicalin significantly reduced serum ALT/GPT,AST/GOT,AKP,HYP and liver index.CONCLUSION Baicalin has a protective effect on hepatic fibrosis induced by CCl4 in mice.

Key concepts: Baicalin, Hydroxyproline, CCL4, Carbon tetrachloride, Hepatic fibrosis, Chemistry, Spleen, Fibrosis

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