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2002•Chinese Journal of Oral & Maxillofacial SurgeryRequires access

SIGNIFICANCE OF EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE mRNA IN NORMAL TONGUE TISSUE AND LEUKOPLAKIA OF TONGUE TISSUE AND SQUAMOUS CELL CARCINOMA OF TONGUE TISSUE

Zeng Shu

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Abstract

Objective To explore the role of nitric oxide in carcinogenesis of tongue. Methods In situ hybridization assay was used to detect the expression of iNOS mRNA which is the key enzyme for the production of NO in 10 cases of normal tongue tissue, 14 cases of leukoplakia of tongue tissue and 68 cases of squamous cell carcinoma of tongue tissue. Results The positive expression rate of iNOS mRNA in normal tongue tissue group and tongue leukoplakia group and tongue squamous cell carcinoma group was 20 0%, 57 1% and 72 1% separetely. The differences among these three groups were significant. Conclusion NO which induced by iNOS may play an important role in carcinogenesis of tongue.

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Objective To explore the role of nitric oxide in carcinogenesis of tongue. Methods In situ hybridization assay was used to detect the expression of iNOS mRNA which is the key enzyme for the production of NO in 10 cases of normal tongue tissue, 14 cases of leukoplakia of tongue tissue and 68 cases of squamous cell carcinoma of tongue tissue. Results The positive expression rate of iNOS mRNA in normal tongue tissue group and tongue leukoplakia group and tongue squamous cell carcinoma group was 20 0%, 57 1% and 72 1% separetely. The differences among these three groups were significant. Conclusion NO which induced by iNOS may play an important role in carcinogenesis of tongue.

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Available abstract

Objective To explore the role of nitric oxide in carcinogenesis of tongue. Methods In situ hybridization assay was used to detect the expression of iNOS mRNA which is the key enzyme for the production of NO in 10 cases of normal tongue tissue, 14 cases of leukoplakia of tongue tissue and 68 cases of squamous cell carcinoma of tongue tissue. Results The positive expression rate of iNOS mRNA in normal tongue tissue group and tongue leukoplakia group and tongue squamous cell carcinoma group was 20 0%, 57 1% and 72 1% separetely. The differences among these three groups were significant. Conclusion NO which induced by iNOS may play an important role in carcinogenesis of tongue.

Key concepts: Tongue, Leukoplakia, Carcinogenesis, Pathology, Nitric oxide synthase, Tongue Neoplasm, In situ hybridization, Nitric oxide

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SIGNIFICANCE OF EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE mRNA IN NORMAL TONGUE TISSUE AND LEUKOPLAKIA OF TONGUE TISSUE AND SQUAMOUS CELL CARCINOMA OF TONGUE TISSUE — Research Paper | ScholarLens