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2010•Chinese Journal of Clinical GastroenterologyRequires access

The Changes of Serum Levels and Clinical Significance of IL-17,IL-10 and TGF-β in Patients with Chronic Hepatitis C After Treatment of PEG-IFNα

Yu Yanlin

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Abstract

Objective To study the expression of serum IL-17,IL-10 and TGF-β in patients with chronic hepatitis C,and to investigate the changes of the three cytokines after treatment of PEG-IFNα.Methods The serum levels of IL-17,IL-10 and TGF-β in 20 patients with chronic hepatitis C before and after treatment of PEG-IFNα were determined by ELISA.Results The serum levels of IL-17,IL-10 and TGF-β in patients with chronic hepatitis C were significant higher than those in normal controls(P0.001),the levels of IL-17,and IL-10 decreased obviously(P0.001) in responsive patients after treatment.-Conclusion IL-17 and IL-10 may participate in the pathogenesis of chronic hepatitis C and may be correlation with histological inflammation.The important clinical significance is showed in judging the result of antiviral treatment.

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Objective To study the expression of serum IL-17,IL-10 and TGF-β in patients with chronic hepatitis C,and to investigate the changes of the three cytokines after treatment of PEG-IFNα.Methods The serum levels of IL-17,IL-10 and TGF-β in 20 patients with chronic hepatitis C before and after treatment of PEG-IFNα were determined by ELISA.Results The serum levels of IL-17,IL-10 and TGF-β in patients with chronic hepatitis C were significant higher than those in normal controls(P0.001),the levels of IL-17,and IL-10 decreased obviously(P0.001) in responsive patients after treatment.-Conclusion IL-17 and IL-10 may participate in the pathogenesis of chronic hepatitis C and may be correlation with histological inflammation.The important clinical significance is showed in judging the result of antiviral treatment.

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Available abstract

Objective To study the expression of serum IL-17,IL-10 and TGF-β in patients with chronic hepatitis C,and to investigate the changes of the three cytokines after treatment of PEG-IFNα.Methods The serum levels of IL-17,IL-10 and TGF-β in 20 patients with chronic hepatitis C before and after treatment of PEG-IFNα were determined by ELISA.Results The serum levels of IL-17,IL-10 and TGF-β in patients with chronic hepatitis C were significant higher than those in normal controls(P0.001),the levels of IL-17,and IL-10 decreased obviously(P0.001) in responsive patients after treatment.-Conclusion IL-17 and IL-10 may participate in the pathogenesis of chronic hepatitis C and may be correlation with histological inflammation.The important clinical significance is showed in judging the result of antiviral treatment.

Key concepts: Medicine, Chronic hepatitis, Pathogenesis, Immunology, Inflammation, Clinical significance, Cytokine, Transforming growth factor

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The Changes of Serum Levels and Clinical Significance of IL-17,IL-10 and TGF-β in Patients with Chronic Hepatitis C After Treatment of PEG-IFNα — Research Paper | ScholarLens