Clinical observation for tiotropium bromide in the treatment of stable chronic obstructive pulmonary disease

Objective To observe the efficacy and adverse reactions of inhaled tiotropium bromide for patients with stable chronic obstructive pulmonary disease(COPD).Methods Eighty-eight COPD cases with a stable phase ofⅡtoⅢwere randomly devided into two groups.The patients in tiotropium bromide group were inhaled tiotropium bromide based on conventional treatment.The patients in control group were administered with conventional treatment.The courses of treatment in both groups were six months.Results Compared with the control group,the times of acute exacerbation of patients in tiotropium bromide group reduced remarkably(P0.05).The clinic symptom grade,score of quality for life and six-minutes walking distance of the tiotropium bromide group were improved significantly.The major adverse reactions were dry mouth and uroschesis.Conclusion Tiotropium bromide(once-daily 18μg inhaled) can significantly reduce the times of acute exacerbation and improve symptoms,exercise tolerance and quality with life of the COPD patients without major adverse reactions.