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Determination of organic solvent residue in Folic acid tablets by headspace GC

Lili Chen

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Abstract

OBJECTIVE To determine organic solvent residue in Folic acid tablets by headspace gas chromatography.METHODSRtx-1(30 m×025 mm,0.25μm) capillary column was used with column temperature was controlled temperature programming,and be set at 200℃.RESULTSThe linear ranges of methanol,acetone,chloroform and methylbenzene were 1.129-24.030 μg·ml-1(r=0.9992),0.566-0.999 μg·ml-1(r=0.9995),1.067-21.030 μg·ml-1(r=0.9995)and 1.264-24.920 μg·ml-1(r=0.9993).The average recovery was 99.2%,100.4%,101.3% and 99.8% with RSD of 1.92%,2.02%,1.64% and 2.01%.CONCLUSIONThe method is simple,accurate,sensitive and reproducible.

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OBJECTIVE To determine organic solvent residue in Folic acid tablets by headspace gas chromatography.METHODSRtx-1(30 m×025 mm,0.25μm) capillary column was used with column temperature was controlled temperature programming,and be set at 200℃.RESULTSThe linear ranges of methanol,acetone,chloroform and methylbenzene were 1.129-24.030 μg·ml-1(r=0.9992),0.566-0.999 μg·ml-1(r=0.9995),1.067-21.030 μg·ml-1(r=0.9995)and 1.264-24.920 μg·ml-1(r=0.9993).The average recovery was 99.2%,100.4%,101.3% and 99.8% with RSD of 1.92%,2.02%,1.64% and 2.01%.CONCLUSIONThe method is simple,accurate,sensitive and reproducible.

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Available abstract

OBJECTIVE To determine organic solvent residue in Folic acid tablets by headspace gas chromatography.METHODSRtx-1(30 m×025 mm,0.25μm) capillary column was used with column temperature was controlled temperature programming,and be set at 200℃.RESULTSThe linear ranges of methanol,acetone,chloroform and methylbenzene were 1.129-24.030 μg·ml-1(r=0.9992),0.566-0.999 μg·ml-1(r=0.9995),1.067-21.030 μg·ml-1(r=0.9995)and 1.264-24.920 μg·ml-1(r=0.9993).The average recovery was 99.2%,100.4%,101.3% and 99.8% with RSD of 1.92%,2.02%,1.64% and 2.01%.CONCLUSIONThe method is simple,accurate,sensitive and reproducible.

Key concepts: Chemistry, Chromatography, Chloroform, Acetone, Residue (chemistry), Solvent, Methanol, Gas chromatography

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