Effects of alanyl-glutamine dipeptide on postoperative intestinal permeability and stress response

Objective: The study was designed to observe the effects of alanyl-glutamine (Aln-Gln) dipeptide on postoperative intestinal permeability and stress response. Methods: A prospective, randomized and controlled trial was taken. 20 patients who underwent abdominal surgery were randomized into two groups: study group [intravenous administration of Aln-Gln dipeptide, 0.5 g/(kg·d), for 4 days, n=10 and control group (normal saline as placebo, for 4 days, n=10)]. Serum concentrations of glutamine (Gln), diamine oxidase (DAO), cortisol, interleukin-6(IL-6) and urine lactulose/mannito (L/M) ratio were measured before and after operation. Results: Serum Gln concentration was significantly decreased in control group and increased in study group on postoperative day 5.Urine L/M ratio was significantly increased in control group and decreased in study group.The serum concentrations of DAO,cortisol and IL-6 were significantly decreased in study group while compared with control group. Conclusion: Administration of Aln-Gln dipeptide can increase the level of serum Gln,decrease the intestinal permeability and attenuate the stress response in the early period of postoperative patients. Aln-Gln dipeptide can be used in the fast track surgery.