2007•Journal of Jiangsu UniversityRequires access
Effect of hypoxic-preconditioning on the structure and function of liver transplanted
Miao Zhang
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Abstract
Objective: To investigate the effect of the hypoxic precondition(HP) on rats liver earlier-stage pathology and function changes after transplantation.Methods: Rats orthotopic liver transplantation(OLT) were according to Kamada two-sleeve approach.Adult male Sprague-Dawley(SD) rats were randomly divided into three groups,A: OLT group,B: HP group,C: normal rats as the control group.Plasma liver functional examination.Liver tissue samples were biopsied for histological study by optic-microscopy.Twelve rats both A and B group were left to observe one week survival rate. Results: The functional lesion of the liver was lessened and cell morphology lesions were slightly compared group B with group A.The one week survival rate in group B was significantly longer than that in group A(P0.05). Conclusion: HP may lessen the pathological lesions of the liver and improve the one week survival rate by elevating hepatocyte tolerance to serious hypoxia damage during orthotopic liver transplantation.