The clinic relevance between acute coronary syndrome and the level of serum matrix metalloproteinase-9

Objective:To investigate the relevance between acute coronary syndrome(ACS) and the level of matrix metalloproteinase-9(MMP-9) . Method:There are 85 coronary heart diseases(CHD)patients diagnosised by CAG including 54 ACS patients, 27 SAP patients,and 24 non-CAD patients are excluded by CAG as the control group and 58 ACS patients are separated into 22 AMI and 36 UAP patients.Every sample's serum MMP-9 level is detected by ELISA method.Result:Before CAG,the concentration of MMP-9 in ACS, SAP, AMI, UAP and control group is ( 26.85± 6.25) μg/L, ( 17.35± 7.12)μg/L, ( 32.56± 6.55)μg/L, ( 24.78± 5.76) μg/L, ( 16.83± 5.92)μg/L reseparately.There are remarkable statistics difference among AMI、UAP and SAP group,and so is it between AMI and UAP group,but there is no remarkable statistics difference between SAP group and control group.There is obvious correlation among the level of serum MMP-9 and the CRP level, WBC number, pathologic coronaries' score、pathologic stenosis' s degree.but there is no obvious correlation between the level of MMP-9 and the pathologic coronaries' number the level of cTnI, CK-MB, TC, TG, HDL-C, LDL-C and the number of platelet.After PTCA,the level of MMP-9 is higher than that before PTCA.Conclution:The concentration of MMP-9 in ACS patients are higher obviously,and they are related to the stability of coronary plaque;MMP-9 contribute to type the CHD and could be the important monitering matkers for CHD in clinic practices.