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2007•Journal of Yanbian UniversityRequires access

Chiral separation of pindolol by reversed-phase high performance liquid chromatography

Dongri Jin

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Abstract

Chiral separation of pindolol by RP-HPLC with a new chiral column Chiral PAKR AD-RH was builded.The effects of the content of mobile phase,pH,column temperature and buffer concentration on the chiral separation of pindolol were discussed.At the optimal conditions,baseline separation of pindolol was achieved.The method could be applied to routine analysis of enantiomers of pindolol and be used for preparation.

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What this paper is about

Chiral separation of pindolol by RP-HPLC with a new chiral column Chiral PAKR AD-RH was builded.The effects of the content of mobile phase,pH,column temperature and buffer concentration on the chiral separation of pindolol were discussed.At the optimal conditions,baseline separation of pindolol was achieved.The method could be applied to routine analysis of enantiomers of pindolol and be used for preparation.

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Available abstract

Chiral separation of pindolol by RP-HPLC with a new chiral column Chiral PAKR AD-RH was builded.The effects of the content of mobile phase,pH,column temperature and buffer concentration on the chiral separation of pindolol were discussed.At the optimal conditions,baseline separation of pindolol was achieved.The method could be applied to routine analysis of enantiomers of pindolol and be used for preparation.

Key concepts: Pindolol, Enantiomer, Chromatography, High-performance liquid chromatography, Chemistry, Chiral column chromatography, Phase (matter), Chiral stationary phase

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