Influence of astragalus injection on serum cytokines and lung function in acute exacerbation of chronic obstructive pulmonary disease

Objective To observe the Influence of astragalus injection on tumor necrosis factor-α(TNF-α),interleukin 8(IL-8),interleukin 2(IL-2) and lung function in acute chronic obstructive pulmonary disease.Methods A total of 112 patients with AECOPD were randomLy divided into the treatment group(56 cases)and control group(56 cases).The treatment group received 40 mL astragalus injection and 5% glucose 250 mL intravenous drip once a day at the base of conventional therapy,while the control group received conventional therapy only.The therapeutic course of both groups was 14 days.The clinical therapeutic effects of both groups were observed,the serum levels of TNF-α,IL-8,IL-2,the lung function and blood gas analysis index of both groups was measured before and after the treatment.Results The treatment group's efective rate was 94.64%,control group was 67.86%,diference was apparent(P 0.05).In the comparison before and after treatment,the levels of TNF-α,IL-8 in both groups were decreased obviously(all P 0.01),while the levels of IL-2 were increased obviously in the two groups(all P 0.01) after the treatment,in the treatment group,the extent of change was significantly greater than that in the control group(all P 0.01).The lung function and blood gas analysis index of both groups were improved obviously,especially in treatment group(all P 0.01).Conclusion Astragalus injection may decrease obviously the serum level of TNF-α and IL-8,increase the level of IL-2,it may improve the lung function and the curative efect in the patients with AECOPD.