Study on chromosome analysis about 1056 cases and its clinical value

Objective:To explore the clinical value of chromosome analysis.Methods:1 056 patients with congenital malformation,growth retardation or mental retardation,micro-testis,infantile uterus,primary or secondary amenorrhea,spontaneous abortion or fetal death were detected in chromosome to analyze the results.Results:164 cases of chromosomal abnormal karyotype accounted for 15.53%.Of them,there were 47 cases of 21-trisomysyndrome(Down's) accounting for 28.66% in the chromosomal abnormal karyotype;there were 61 cases of sex chromosome abnormality accounting for 37.20% in the chromosomal abnormal karyotype;45 cases(6.71%) of the chromosomal structural abnormality,11 cases(6.71%) chromosome polymorphism.Conclusion:Thus,these results indicate that chromosomal abnormal karyotype in human is the main cause of congenital malformation,hypoplasty of sexual organs,recurrent abortion and infertility.