Hemodynamic responses of esmolol to nasotracheal intubation with fiberbronchoscope

Objective To evaluate the hemodynamic responses of esmolol to nasotracheal intubation with fiberbronchoscope(FOB). Methods Thirty-five ASAⅠorⅡpatients undergone stomatology and otorhinolaryngology surgery were randomly divided into fiberoptic nasotracheal intubation esmolol group (esmolol group) and fiberoptic nasotracheal intubation group (control group). The intravenous administration of esmolol 1mg·kg-1 was performed 2 min before tracheal intubation in esmolol group. Noninvasive SBP,DBP,MBP,HR and SpO2 were recorded before and after anesthetic induction,at intubation and 1,2,3,4,5 min after intubation. Results The SBP,DBP and MBP 1 min after intubation in esmolol group were significantly lower than those in control group(P0.05). The HR at intubation in esmolol group was significantly lower than that in control group(P0.05). The maximums of SBP,DBP,MBP and HR in esmolol group were also lower than those in control group(P0.05). The SpO2 levels in two groups were above 96% during the test. Conclusion General anesthesia of clinical standard depth cannot inhibit effectively the increase of blood pressure and heart rate caused by nasotracheal intubation through FOB;Introvenous administration of esmolol 1 mg·kg-1 2 min before tracheal intubation can effectively inhibit cardiovascular responses caused by nasotracheal intubation through FOB.