Association of cystatin C,Interleukin-6 and acute phase protein with chronic renal insufficiency

Objective To evaluate the difference and correlation of the serum levels of cystatin C(Cys C),Interleukin-6(IL- 6) and acute phase reactive protein(CRP) in different stages of chronic renal insufficiency.Methods Eighty-four patients(E group) with renal disfunction were divided into three groups according to their creatinine clearance(Ccr):28 cases compensatory stage of renal insufficiency group,28 cases the Loses compensatory stage of renal insufficiency group and 28 cases Kidney function weakness group.28 cases healthy individuals were normal controls.Serum glucose(GLU),Cys C,creatinine(Scr),urea(BUN),IL-6,C-reactive protein(CRP),ceruloplasmin(CER) and transferin(TRF) levels were determined.Results The age and GLU values were no significant difference between every two groups(P0.05).The Scr,BUN,CER,Levels were higher in B group than those in A group,but no significant difference could be found(P0.05).However,the Serum levels of Scr,BUN,CER among B,C,D group and Cys C,IL-6,transferin(TRF) between every two groups were significantly difference(P0.01 or P0.05),The Cys C,IL-6, CRP,Scr,BUN,CER levels were linearly positively correlated with each other(P0.01),linearly negatively correlated with Ccr and TRF.Conclusion There is an acute phase reaction in all stages of chronic renal insufficiency,and the degree of acute phase reaction is correlated with the severe of kidney impairment.There is important significance for the combined detected of the serum Cys C,IL-6,CRP and other biochemical indicators to evaluate the degree of kidney disease.