Optimization of fermentation medium for lovastatin production by orthogonal experiment

In order to determine the optimal fermentation medium for lovastatin production by Aspergillus terreus,the optimal concentration of carbon,nitrogen and mineral salt were determined by single-factor test firstly.Then,the optimal fermentation medium was obtained by orthogonal design as followed: starch 3.5%,soybean meal 4.25%,sodium citrate 0.10% and potassium dihydrogen phosphate 2.0g/L.Under these conditions,the highest lovastatin production was obtained.