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Optimization of Experimental Conditions on Lovastatin Yield Through Monascus

Shen Ping, Wu Jun, Haoran Li, Feng Ya-li

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Abstract

In this experiment,the operational factors on lovastatin yield by solid-state fermentation were studied by orthogonal design. The result showed that the optimum conditions was temperature 25℃, 11d of fermentation time, 3% of soluble starch as additive carbon source, 10% of water supplement from the third day, no MgSO (4)and 0.1% of KH (2)PO (4), 0.2% of NaNO (3) as additive nitrogen source and pH 4.5.

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What this paper is about

In this experiment,the operational factors on lovastatin yield by solid-state fermentation were studied by orthogonal design. The result showed that the optimum conditions was temperature 25℃, 11d of fermentation time, 3% of soluble starch as additive carbon source, 10% of water supplement from the third day, no MgSO (4)and 0.1% of KH (2)PO (4), 0.2% of NaNO (3) as additive nitrogen source and pH 4.5.

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Available abstract

In this experiment,the operational factors on lovastatin yield by solid-state fermentation were studied by orthogonal design. The result showed that the optimum conditions was temperature 25℃, 11d of fermentation time, 3% of soluble starch as additive carbon source, 10% of water supplement from the third day, no MgSO (4)and 0.1% of KH (2)PO (4), 0.2% of NaNO (3) as additive nitrogen source and pH 4.5.

Key concepts: Lovastatin, Monascus, Yield (engineering), Starch, Fermentation, Corn starch, Carbon source, Chemistry

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