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Preliminary research on intrahepatic cholestasis of pregnancy impact on fetus

Liu Chu

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Abstract

Objective To explore the effection of intrahepatic cholestasis of pregnancy(ICP)on the fetus.Methods Forty cases of ICP full-term pregnant women in the observation group(ICP group),40 cases of normal full-term mothers as the control group,measured umbilical vein serum bile acid(TBA),ALT,AST and TNF-α after delivery respectively.Results The umbilical vein serum bile acid(TBA),ALT,AST and TNF-α of ICP group were significantly higher than those of the normal group(P0.05).Conclusion ICP can cause fetal liver dysfunction and increase fetal harmful cytokines.

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What this paper is about

Objective To explore the effection of intrahepatic cholestasis of pregnancy(ICP)on the fetus.Methods Forty cases of ICP full-term pregnant women in the observation group(ICP group),40 cases of normal full-term mothers as the control group,measured umbilical vein serum bile acid(TBA),ALT,AST and TNF-α after delivery respectively.Results The umbilical vein serum bile acid(TBA),ALT,AST and TNF-α of ICP group were significantly higher than those of the normal group(P0.05).Conclusion ICP can cause fetal liver dysfunction and increase fetal harmful cytokines.

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Available abstract

Objective To explore the effection of intrahepatic cholestasis of pregnancy(ICP)on the fetus.Methods Forty cases of ICP full-term pregnant women in the observation group(ICP group),40 cases of normal full-term mothers as the control group,measured umbilical vein serum bile acid(TBA),ALT,AST and TNF-α after delivery respectively.Results The umbilical vein serum bile acid(TBA),ALT,AST and TNF-α of ICP group were significantly higher than those of the normal group(P0.05).Conclusion ICP can cause fetal liver dysfunction and increase fetal harmful cytokines.

Key concepts: Cholestasis of pregnancy, Medicine, Fetus, Bile acid, Umbilical vein, Cholestasis, Pregnancy, Internal medicine

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