2011•Chinese Journal of Gastroenterology and HepatologyRequires access
Clinicopathological significance and expression of miR-21 in colorectal carcinoma and tumor-adjacent normal colorectal tissue
Hua Huang
Open publisher page 0 citations
Abstract
Objective To investigate the expression of miR-21 in colorectal carcinoma(CRC) and tumor-adjacent normal colorectal tissue and analyze its clinicopathological significance.Methods The expression of miR-21 in the colorectal carcinoma and tumor-adjacent normal colorectal tissue was detected by real-time florescence quantitative PCR.Data analysis was performed by relatively quantitative method,the differential expression of miR-21 was observed in the different characteristics of colorectal carcinoma.Results The expression of miR-21 in CRC was up-regulated compared with tumor-adjacent normal colorectal tissue.Furthermore,the expression of miR-21 was related to the biological characteristics of CRC cancer cells.Conclusion The expression of miR-21 is related to the degree of differentiation,lymphatic node metastasis and hepatic metastatic cancer.The over-expression of miR-21 may play a role in the development and progression of CRC.