A clinical observation of the effect of paroxetine with small-dose quetiapine in depression

Objective:To study the clinical effect of paroxetine with small-dose quetiapine(200mg/d) in the treatment of depression. Methods:80 hospitalized patients who met CCMD-3 criteria of depression were randomly divided into search(paroxetine and quetiapine) group and control(paroxetine) group for the treatment of 8 weeks.The efficacy and side effects were evaluated with HAMD and TESS.The relapse of one year was observed by follow up.Results: The treatment of paroxetine with quetiapine was effective and the tolerance was better.There were significant differences in recovery rate,HAMD of first week,second week;forth week and HAMD gene score of symptom of body discomfort,sleep disorder and orexis after treatment between two groups.But there was no difference in TESS and the relapse of one year between two groups.Conclusions: Paroxetine with small-dose quetiapine could improve the efficacy compared with paroxetine in treating depression,and could improve sleep orexis and the feeling of body discomfort..But quetiapine had no distinct effect on relapse.