2010•Academic Journal of Second Military Medical UniversityRequires access

Expression of human giant larvae-1 in ovarian cancer and its clinical significance

Hui Ning

Abstract

Objective To study the expression of human giant larvae-1 (Hugl-1) in ovarian carcinoma and its clinical significance.Methods Hugl-1 mRNA expression in 31 ovarian cancer and the corresponding adjacent tissues was examined by real time fluorescence quantitative RT-PCR and in situ hybridization.Moreover,analysis was done while taking into consideration of the clinicopathologic parameters of ovarian cancer.Results The expression of Hugl-1 mRNA in ovarian cancer tissue was significantly higher than that in the corresponding adjacent tissues ([0.051 ± 0.029]vs [0.026 ± 0.043],P 0.01);and the expression was not related to patient age,serum CA125 status,pathological characteristics or clinical stages of tumors.Conclusion Hugl-1 may play a role in the development and progresssion of ovarian cancer.

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Key concepts: Ovarian cancer, Clinical significance, Pathological, Ovarian carcinoma, Pathology, Cancer, In situ hybridization, Stage (stratigraphy)