Study of the Ralationship of HDN and the Different Blood Types Between Mother and Baby

Objective To investigate the relationship between O、A and B blood type of newborn and blood group antibody titer in pregnant women and to clear the influence of the antibody's level and the hemolytic disease of newborn (HDN).Methods Detect 413 pregnant woman's blood type antibody IgG who is O positive with a A or B husband.After been born,ABO blood groups,coomb's test,free antibody and antibody release test were done for those 69 babies who were in high risks of HDN, so that we would understand the relationship between the level of blood type antibody IgG of O type pregnant women and HDN.Results The percent of anti-A(B) IgG titer ≥64 in the 413 women was 61.7%.The titer was different between A or B group babies' mothers and O group babies' mothers.The difference was remarkable.The titer was identical in mothers who had A or B babies.There were 25 babies suffered from HDN in those 69 who had high risk, the percent was 36.2%.The ratio of HDN was concern with the titer of mothers' IgG,the higher the titer was the higher the ratio was.Conclusion The babies' blood type affected the level of anti-A(B)IgG of the mothers when they were different but weather baby was A or B had no direct relationships with the level of the antibody.There was a positive relationship between the level of blood type antibody IgG of O type pregnant women and hemolytic disease of newborn (HDN).